Associate Principal Scientist - Modelling and Simulation

At AstraZeneca,we’rededicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit.There’sno better place to make a difference tomedicines,patientsand society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning,growthand development.

InPharmaceutical Technology & Development(PT&D), withinAstraZenecaOperations,we believe that nothing is impossible, and we are determined to push the boundaries of science to deliver medicines to our patients. We combine people’s technical knowledge and understanding with their talent and drive to design, develop and optimise processes that deliver our medicines in a sustainable, commerciallyviableway.Our ambition is toestablisha strong predictive science culture by utilisation of state-of-the art modelling and simulation technologiesto carry out our research and experimental work in the most efficient way.

To achieve our bold ambition, we have an open position foranexperience scientist/engineerintheModelling& Simulation team.

The role

In this role you will join the modelling and simulation team to develop and implement predictive tools to accelerate development of robust drug substanceand drug productmanufacturing processes. You willworkwith project teams, process engineers,mathematicians,chemists,pharmacists,materialsand data scientists as well asanalyticaland artificial intelligenceexperts,to build andvalidatemodels, perform in-silicoanalyses, and interpret results for decision making on projects.

Responsibilities:

• Develop andutilisedigital twins in drug substanceand drug productmanufacturing process development toestablishmanufacturing processes as well asde-risk scaleup and tech-transfer by in-silico design space exploration and process optimisation.

• Work closely with modelling and simulation team, subject matter expertsand project associates to developappropriate workflowsfor utilisation of predictive tools inpharmaceuticaldevelopment and for exploitation in manufacture.

• Coach and upskill process engineers by delivering trainings/workshops and sharing good practices of using modelling and simulation tools inpharmaceutical development.

• Support defining andestablishingmodel/data standards, workflows for modelverification andvalidation, data collection, experiment conditions and sampling, etc.

• Drivedemocratisation of modelling and simulation tools by developing automated,documentedand verifiedworkflows to make simulation tools accessible toa wider community of process engineers,chemistsand pharmacists.

• Keep abreast of global developments in your area by attending relevant events such as conferences, webinars, and workshops and being active member of relevant networks and working groups.

• Ensure access tostate-of-the-arttools and technologies through engaging in pre-competitive collaborative projects, initiatives with academia and software vendors, etc.

Essential skills and qualifications:

• PhD or MSc/MEng in chemical engineering,physics, chemistry,mathematicsor related discipline.

• A few years post-graduate industrial work experience inarelevant field.

• Experience using modelling and simulation tools likegPROMS,DynoChem, Aspen, AnsysFluent/CFX, AnsysRockyor similar software packages in research or industrial projects.

• Strong coding skills and experience of using standard programming languages like Python, MATLAB, etc.

• Ability tobuildmathematical models of physical/chemicalphenomenaand solve them usingappropriate codingtools.

• Ability tomodify/enhance existing models to improve their efficiency/predictability and/or upgrade their functionality for a new context of use.

• Excellentwritingand communication skills.

• Cultural awareness

Desirable skills:

• Experience using computational fluid dynamics (CFD) and/or discrete element method (DEM) tools insimulatingofcomplex,multi-physics systems(e.g.multiphase flow).

• Experience with process scale-up and working knowledge of unit operations (e.g.reactors, mixing, distillation,extraction, membrane, chromatography,crystallization,filtration,drying,etc.) in pharmaceutical drug substance manufacturing.

• Experience developing and implementingmodel-assisted process control (e.g., coupling PSE’sgPROMSandPharmaMV, etc.)

At AstraZeneca, we are driven by our commitment to deliver accelerated growth and make people's lives better. We thrive on innovation and collaboration, constantly seeking new challenges and solutions. Our inclusive environment supports personal growth and development while working towards our shared goal of transforming molecules into medicines. With a focus on sustainability andcutting-edgescience, we are dedicated to making a positive impact on global health.

Ready to make a difference? Apply, with your CV and cover letter, no later thanMarch 31st2025!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.